Drug Week
Medicine & Law Weekly
July 23, 2004
ALZHEIMER DISEASE;
Polypeptide protects brain neurons in aluminum neurotoxicosis
Hypothalamic proline-rich polypeptide protects brain neurons in
aluminum neurotoxicosis.
According to recent research from Armenia, “The damaging effect of
aluminum ions (Al) on the organism is widely investigated in clinics
and experiments that indicate its role as a participant in the
synthesis of precursors for amyloid proteins and as a potential agent
in the etiology of Alzheimer disease.
It has been shown that aluminum produces neurotoxic effects. We
established that AlCl produces degenerative changes in the
ultrastructure of Hasserian neurinoma cells in vitro and in L-929
fibroblast cells.”
“Proline-rich peptide-1 (PRP-1) isolated from neurosecretory granules
of bovine neurohypophysis is a potent antineurodegenerative agent
against spinal cord hemisection and crush syndrome-induced
neurodegeneration of brain and spinal cord neurons,” reported A. A.
Galoyan and colleagues at the M. Heratsi State Medical University in
Armenia and the Russian Academy of Sciences. “PRP-1 is one of the
neurotrophic brain factors. By electron microscopic study of the rat
hippocampus and other tissues, we succeeded in visualizing the
epithelioprotectory effect of PRP-1, contributing as a powerful agent
in removal of aluminum accumulation in different tissues in
experimental aluminum neurotoxicosis.”
Galoyan and associates published their study in Neurochemical
Research (Hypothalamic proline-rich polypeptide protects brain
neurons in aluminum neurotoxicosis. Neurochem Res,
2004;29(7):1349-1357).
For additional information, contact A. A. Galoyan, H. Buniatian
Institute of Biochemistry, Sevag Str, Yerevan 375014, Armenia.
E-mail: [email protected].
Publisher contact information for the journal Neurochemical Research
is: Kluwer Academic, Plenum Publishing, 233 Spring Street, New York,
NY 10013, USA.
The information in this article comes under the major subject areas
of Alzheimer Disease, Neurodegeneration, Neuroscience, Neurotoxin,
Neurology, and Proteomics.
From: Emil Lazarian | Ararat NewsPress