Scientists at YSU Dept of Physiology, target chronic heart failure

Cardiovascular Device Liability Week
August 26, 2007

Scientists at Yerevan State University, Department of Physiology
target chronic heart failure

Fresh data on chronic heart failure are presented in the report
"Calcium-regulating peptide hormones and blood electrolytic balance
in chronic heart failure. Calcium-regulating system is important for
the functional activity of myocardium. However, little is known about
the role of this system in the pathogenesis of cardiovascular
diseases," researchers in Yerevan, Armenia report.

"Blood samples from the patients with chronic heart failure (CHF)
caused by ischaemic disease (coronary artery disease) (NYHA class
I-IV) were used to analyze the levels of calcium, inorganic
phosphate, sodium, potassium, parathyroid hormone (PTH) and
parathyroid hormone-related protein (PTHrP). The heart beat rate and
arterial blood pressure were chosen as additional tests for the
functional status of cardiovascular system. The alteration of
electrolytes homeostasis was found dependent on the severity of the
pathology being maximally expressed in the NYHA class IV patients.
Similar tendency was demonstrated for circulating PTH and PTHrP with
the highest blood concentrations observed in patients of the NYHA
class III and IV. The extent of these changes was found more
pronounced in the female patients," wrote K.P. Arakelyan and
colleagues, Yerevan State University, Department of Physiology.

The researchers concluded: "It is suggested that the
calcium-regulating hormonal system is involved in the pathogenesis of
the ischaemic heart disease; however the sharp increase of PTH and
PTHrP at the severe stages of pathology may play a compensatory role
in maintaining the heart function."

Arakelyan and colleagues published their study in Regulatory Peptides
(Calcium-regulating peptide hormones and blood electrolytic balance
in chronic heart failure. Regulatory Peptides, 2007;142(3):95-100).

For additional information, contact K.P. Arakelyan, Yerevan State
Medical University, Dept. of Physiology, 375025 Yerevan, Armenia.

Publisher contact information for the journal Regulatory Peptides is:
Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

This article was prepared by Cardiovascular Device Liability Week
editors from staff and other reports. Copyright 2007, Cardiovascular
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