Scientists at Institute of Biotechnology target enzyme research

Drug Week
September 11, 2009

ENZYME RESEARCH;
Scientists at Institute of Biotechnology target enzyme research

Data detailed in ‘The novel inhibitors of serine proteases’ have been
presented. According to a study from Yerevan, Armenia, "Thirty
optically active nonprotein alpha-amino acids and peptides based
thereon have been screened for their ability to interact with bovine
trypsin and proteinase K from Tritirachium album Limber, which belong
to the group of serine proteases. Both structure-based drug design
approach and determination of enzyme activity have been used to
identify low molecular weight inhibitors of trypsin and proteinase K."

"Compounds have been selected that according to the docking analysis
were able to interact with trypsin and proteinase K. Following the
docking analysis measurement of enzymes activity
(2R,3S)-beta-hydroxyleucine and (2S,3R)-beta-hydroxyleucine inhibited
both enzymes activity, whereas (S)-alpha-methyl-beta-phenylalanine,
®-alpha- methyl-beta-phenylalanine, (S)-allylglycine, ®-allylglycine,
(S)-alpha-allylalanine, ®-alpha-allylalanine and allo-O-ethylthreonine
inhibited only proteinase K; and
N-formyl-(S)-methionyl-(2S,3R)-hydroxyleucine,
N-formyl-(S)-methionyl-(2R,3S)-hydroxyleucine,
N- formyl-(S)-methionyl-(S)-allylglycine and
N-formyl-(S)-methionyl-®-allylglycine inhibited trypsin," wrote
N. Hovhannisyan and colleagues, Institute of Biotechnology (see also
Enzyme Research).

The researchers concluded: "It has been shown that inhibition of
trypsin by (2R,3S)-beta-hydroxyleucine and
N-formyl-(S)-methionyl-(2R,3S)-hydroxyleucine is of a competitive
mode."

Hovhannisyan and colleagues published their study in Amino Acids (The
novel inhibitors of serine proteases. Amino Acids, 2009;37(3):531-6).

For more information, contact N. Hovhannisyan, Institute of
Biotechnology, Yerevan, Armenia.

Publisher contact information for the journal Amino Acids is:
Springer, 233 Spring Street, New York, NY 10013, USA.

Another Exposure Of Azeri Media

ANOTHER EXPOSURE OF AZERI MEDIA

Information-Analytic Agency NEWS.am
Sept 11 2009
Armenia

10:13 / 09/11/2009Azeri mass media is cheating again. To frustrate
Nagorno-Karabakh peace process, Baku casts prudence to the winds
disdaining apparent juggling with facts.

Yesterday, a number of Azeri information agencies reported the
exchange of fire into Aghdam contact-line in Karabakh conflict
zone. Azeri media referring to unofficial sources informed that
allegedly during the firing five Armenian servicemen were killed,
whereas one got wounded from Azeri side.

NKR Defense Ministry has officially denied the information.

Thus, on Sept.10, Azeri side decided to load the glaring misinformation
by new facts and publish a photo of the "killed" Armenian
serviceman. The article in Russian is available on Vesti.az. As a
matter of fact, in truth it is a picture of 2008 August war in Georgia
with a body of Georgian soldier. To get the evidence of the absolute
truth, please see photo session at RF Communist Party official website.

Government’s Anti-Crisis Program Should Be Implemented At Fast Paces

GOVERNMENT’S ANTI-CRISIS PROGRAM SHOULD BE IMPLEMENTED AT FAST PACES

PanARMENIAN.Net
11.09.2009 13:04 GMT+04:00

/PanARMENIAN.Net/ Government’s anti-crisis program should be
implemented at fast paces since its principles and clauses inspire
positive hopes, said Arsen Kazaryan, Head of RA Union of Industrialists
and Entrepreneurs. According to him, Government’s operating headquarter
approved several programs in February-March 2009 but their funding
begins just now.

Kazaryan also noted that a couple of months ago mortgage market
participants, particularly Elite Group company, were issued state
guarantee which increased construction volumes in July-August. "Over
the past 7-8 years, construction sphere ensured 30-40% of our economic
growth. But currently, economic downfall is on the level of 15-16%. No
wonder if we register certain negative growth by the end of 2009,"
he added.

Speaker stressed the importance of state-business-private
sector cooperation which will help overcome the impact of global
financial-economic recession. "As I see, my partners never lose their
spirits," he added.

Armenia too, is experiencing the hardships of world crisis, although
not in the same volumes as big economies, entrepreneur finds. "I hope
we’ll register certain stabilization by 2010, summing up the current
year with minimal losses," he said.

Ashot Kocharyan Appointed As RA Ambassador To Lebanon

ASHOT KOCHARYAN APPOINTED AS RA AMBASSADOR TO LEBANON

/PanARMENIAN.Net/
10.09.2009 10:59 GMT+04:00

/PanARMENIAN.Net/ By RA President Serzh Sargsyan’s decree, RA
Ambassador to India Ashot Kocharyan is relieved of the position
occupied and appointed as RA Ambassador to Lebanon with a residence
in Beirut.

By another presidential decree, Ashot Osikyan was appointed as Deputy
Chief of RA police.

ANKARA: Baykal asks for clarity on Kurdish, Armenian moves

Hurriyet Daily News, Turkey
Sept 6 2009

Baykal asks for clarity on Kurdish, Armenian moves

Sunday, September 6, 2009
ANKARA ` Hürriyet Daily News

The main opposition party has asked the government to clarify the
motives behind its recent initiatives on the Kurdish issue and
relations with Armenia and repeated that it would not be a part of
such moves.

`Don’t count us in. We are not going to be your fellow travelers; you
have already some other fellows. Bon voyage to you! But I advise you
to return from this journey as soon as possible,’ Deniz Baykal, the
leader of the Republican People’s Party, or CHP, said over the
weekend.

Baykal’s words were a response to Prime Minister Recep Tayyip
ErdoÄ?an, who has said his party would knock on the CHP’s doors
if it does not consent to meet.

`The government’s move is putting Turkey under the pressure of an
ethnic identity. However, the majority of our citizens of Kurdish
origin have no problem being part of the national identity,’ Baykal
said.

Arguing that as a result of the government’s approach to the issue, a
minority group that is focused on dissociation rather than integration
with the rest of the country has been accepted as speaking for all
Kurds, Baykal said: `This point is disturbing both Kurds and Turks. On
purpose or not, they are doing wrong.’

According to the CHP leader, the government’s Kurdish move has nothing
to do with the democratization of the country. `You cannot stop
terrorism through encouraging dissociation. That, in fact, would
encourage the terror,’ he said, adding that negotiating with those who
seek separation would bring nothing but more problems.

Baykal also argued that the government is, in fact, aware of the road
map produced by Abdullah Ã-calan, the imprisoned leader of the
outlawed Kurdistan Workers’ Party, or PKK, but cannot make it public
due to the growing reactions. `With this government’s move, Ã-calan
has become a political figure. The DTP [or pro-Kurdish Democratic
Society Party] says that the real interlocutor is Ã-calan,’ he
said.

Questions on Armenian move

The CHP leader also expressed reservations about the government’s
Armenian move. Noting that the protocols aiming at normalizing
relations between Turkey and Armenia were initialized April 2, just
days before U.S. President Barack Obama’s visit to Turkey, Baykal said
he had asked President Abdullah Gül whether the two had raised
the issue of protocols during their meeting.

‘I just want to learn. [They were] initialized in April, announced
now. ¦ It has not been written down, but the Americans are in
expectation [of the signing of protocols],’ he said. `The president
will make a statement either to confirm or to deny.’

aykal-asks-clarity-on-kurdish-armenian-moves-2009- 09-06

http://www.hurriyetdailynews.com/n.php?n=b

Only 3 out of 9 Armenian boxers make it to 1/8 finals

Only 3 out of 9 Armenian boxers make it to 1/8 finals
07.09.2009 09:51 GMT+04:00 l

/PanARMENIAN.Net/ In 1/8 finals of Milan World Championship Armenia
will be represented by 3 boxers only: Hovhannes Danielyan (48 kg),
Azat Hovhannesyan (57 kg) and Andranik Hakobyan (75kg).

Hovhannes Danielyan (48 kg), unlike other representatives of Armenian
team, entered the field in 1/16 finals, beating Harry Tanamor of
Philippines 11:3.

Azat Hovhannesyan have been fighting twice, defeating Hektor Mansania
of Venezuela in 1/32 finals and Jitis Vaitkus of Lithuania in 1/16
finals.

Andranik Hakobyan made it to 1/8 finals, having beaten Iraqi boxer
Abdulrid Vahid and Swedish boxer Naim Terbunja.

In 1/8 finals Danielyan will combat against South African boxer
Lebogang Pilane, Hovhannesyan will rival Alessio Di Savino of Italy
and Hakobyan fight against Irish boxer Darren O’Neal on September 7
and 8.

President Serzh Sargsyan Appoints Aharon Chilingarian Member Of Cent

PRESIDENT SERZH SARGSYAN APPOINTS AHARON CHILINGARIAN MEMBER OF CENTRAL BANK BOARD

/ARKA/
September 4, 2009
YEREVAN

YEREVAN, September 4, /ARKA/. Armenian President Serzh Sargsyan signed
a decree on September 3 to appoint Aharon Chilingarian a member of
the Central Bank Board for a term of 4 years.

Before this new appointment Aharon Chilingarian served as first deputy
head of the State Revenue Committee.

By another decree president Sargsyan relieved Karine Minasian of her
duties of a member of Central Bank Board.

The government press office said Karine Minasian was appointed first
deputy head of the State Revenue Committee.

ANKARA: Opposition: No Vote For Protocols Unless Nagorno Occupation

OPPOSITION: NO VOTE FOR PROTOCOLS UNLESS NAGORNO OCCUPATION ENDS

Hurriyet Daily News
Sept 3 2009
Turkey

The two main opposition parties have said they will not back the
normalization process with Armenia without the withdrawal of Armenian
forces from Azerbaijan’s Nagorno-Karabakh region.

"We will not go to vote in favor of the protocols at Parliament
unless the occupation ends," Deniz Baykal, leader of the Republican
People’s Party, or CHP, said during a party meeting late Wednesday,
the Anatolia news agency reported.

Baykal emphasized that although the protocols set a clear dateline
for the opening of the common border with Armenia, it does not give
assurances on Armenia’s withdrawal from Azerbaijani lands. Recalling
Prime Minister Recep Tayyip Erdogan’s promise to Azerbaijan not to
open the border before the Nagorno-Karabakh problem was settled, Baykal
said the government obviously ran into a contradiction with the move.

He also said taking the protocols to Parliament were obligatory and
not a government pledge to the opposition. "The issues that were
introduced as Armenia’s compromises have no validity in fact. What we
have to see is our compromises. It’s not certain on what conditions
these compromises were made," he said.

Devlet Bahceli, leader of the Nationalist Movement Party, or MHP,
accused the ruling party of ignoring Turkey’s national interests
and its closest ally, Azerbaijan. "We’ll not vote in favor of
the protocols," he said, in a written statement. However, as the
ratification of international documents requires a simple majority,
the ruling party will have no need for the support of the opposition.

Another Success And A New Challenge For Turkey’s Gas Diplomacy

ANOTHER SUCCESS AND A NEW CHALLENGE FOR TURKEY’S GAS DIPLOMACY
Andrea Bonzanni

World Politics Review
aspx?id=4243
Sept 2 2009

Less than a month after making progress on the Nabucco pipeline deal,
which has now secured half of the gas needed to fill it, Turkey signed
another natural gas agreement in early August that will allow access
into Turkish territorial waters to the South Stream pipeline. South
Stream, a Russian-Italian venture, is designed to bring Russian
gas to Bulgaria while bypassing troublesome transit countries on
the route between the Russian Federation and the European Union. A
few days later, Turkey also held discussions with the emir of Qatar,
Hamad bin Khalifa Al-Thani, on pipeline and liquefied natural gas (LNG)
projects, as well as with Syrian Petroleum Minister Sufian Al-Allao on
network interconnections that may carry Egyptian natural gas to Turkey.

The agreements reveal Turkey’s bold strategy in gas diplomacy,
particularly its determination to receive as much gas as possible
regardless of the source. Part of this dash to gas is surely
justifiable by growing domestic needs. Turkish consumption witnessed
a tenfold increase between 1990 and 2006, boosted by 4.5 percent
average annual GDP growth. An aggressive process of gasification of
the country’s energy supply, led by state-owned giant BOTAS, also
contributed to the increase.

However, Turkey’s aggressive pursuit of gas supplies can not
be fully explained by domestic demand. Rather, it is clear that
Turkey nurtures ambitions of becoming a gas-hub, exploiting its
geographical position to take full political advantage of the regional
gas-trading system. The details of the South Stream agreements are
quite straightforward in this respect, with the establishment of a
consortium to build a new pipeline across the Anatolian Peninsula
from the Black Sea to the Mediterranean for future trans-shipments
to Cyprus and Israel. Further, Russia will provide assistance for
the construction of nuclear plants that will reduce Turkey’s need
for gas and increase its capacity to re-export.

Things have so far gone in the right direction for
Turkey. Participating in both Nabucco and South Stream was already a
great diplomatic achievement, especially given the degree of animosity
between the two consortia. Moreover, although observers have always
viewed the two pipelines as mutually exclusive alternatives, both
projects have reached such an advanced stage that it is now possible
they will both see the light of day. This will make Turkey the transit
route for no less than 94bcm of gas a year, an amount close to a
fifth of total EU consumption in 2007.

Ankara is also seeking to be the gateway for European imports of
Iranian gas. The Islamic Republic has long explored the possibility
of building pipelines to Europe, and pressures are now mounting
due to Iran’s rising population, unemployment and budget deficit. A
first important step in this direction was accomplished in 2001 with
the construction of the Iran-Turkey pipeline, which brings 30mcm
of natural gas from the northwestern Iranian city of Tabriz to
Ankara. However, Iranian export potential is immensely larger and
the Turkish government, well aware of that, is closely following
Iranian political developments, a topic that was at the top of the
agenda during U.S. President Barack Obama’s visit to the country
last April. In the event that the U.S. lifts its informal veto on
gas exploitation in Iran, Turkey will be the natural transit route
to Europe for a country with the second-largest proven reserves in
the world after Russia.

Even the recent rapprochement with Armenia that culminated in the
announcememnt yesterday of the upcoming establishment of diplomatic
ties and a reopening of borders, although officially justified under
the "zero problems with neighbors" policy put forward by Foreign
Minister Ahmet Davutoglu, has to be partly understood in light of
recent events in pipeline politics. The AKP leadership has in fact
demonstrated a long-term vision for the country’s future and, given
the prolonged political instability in Georgia, it simply does not
want to rule out a precious potential alternative route for Caspian
hydrocarbons on purely ideological grounds. This also explains Turkey’s
desire for a full resolution of the Nagorno-Karabakh conflict between
Armenia and resource-rich Azerbaijan, which would finally bring
regional stability.

In addition, good relations with Armenia are instrumental to the
full success of Turkey’s plans, not least because of the improvement
in Turkey’s reputation that will result. Indeed, trust-building is a
necessary condition, as European governments have to be fully convinced
that Turkey is a reliable partner that can guarantee the security of
gas supplies. With Turkey’s accession to the EU currently a remote
possibility, it seems unlikely the Europe would grant Ankara such a
crucial role in the diversification of its gas supplies unless it is
certain that Turkey will prove to be different from Russia, Ukraine
and Belarus. This confidence deficit is Turkey’s real challenge in
the near future, and last month’s rejection of the Turkish bid to buy
15 percent of the gas transiting on its territory through Nabucco,
a plan that would have provided the country with enough leverage to
affect regional prices, is a sign that European negotiators are not
yet fully convinced of Turkey’s intentions.

Erdogan and the AKP have so far been extremely successful in playing
on the chessboard of Eurasian pipeline diplomacy. However, the most
difficult part seems to be coming now. Turkey has proven itself
skillful when it comes to being pragmatic and canny. Now it must
demonstrate the same ability to navigate the qualitatively different
and more values-based landscape of intra-European politics.

Andrea Bonzanni is a post-graduate student at the Graduate Institute
of International and Development Studies in Geneva and collaborates
with the Sustainable Energy Division of the United Nations Economic
Commission for Europe. The views expressed here are his alone.

Photo: Turkmen Deputy Prime Minister for Oil and Gas Tachberdy Tagiyev
and Turkish President Abdullah Gul at an EU summit discussing the
Southern Corridor and the Nabucco pipeline, May 2009 (EU Commission
photo).

http://www.worldpoliticsreview.com/article.

U.S. Hopes For Soonest Opening Of Armenia-Turkey Border

U.S. HOPES FOR SOONEST OPENING OF ARMENIA-TURKEY BORDER

Interfax
Aug 31 2009
Russia

The United States supports the settlement of Armenian-Turkish relations
and the opening of borders, U.S. Ambassador Marie L. Yovanovitch said
on Monday.

The United States hopes that Armenia and Turkey will soon make
substantial progress, the ambassador noted.

There are no diplomatic relations between Armenia and Turkey, and
the border was closed in 1993 at Ankara’s initiative. Turkey said
that Armenia must pull out of Nargoro-Karabakh and recognize the
territorial integrity of Azerbaijan. Armenia offered to normalize
relations with Turkey without preconditions.

The Armenian president was invited to watch a soccer game of the
Armenian and Turkey national teams in Turkey on October 14. Turkish
President Abdullah Gul watched a similar game in Armenia last
September.

That was his first ever visit to Yerevan.