Two Americans win Medicine Nobel for work on heat and touch

Reuters
Oct 4 2021
By Johan Ahlander and Ludwig Burger
  • Americans Julius and Patapoutian win Nobel medicine prize
  • Discoveries of receptors for temperature, touch recognised
  • Discoveries could pave the way for new pain-killers

STOCKHOLM, Oct 4 (Reuters) – American scientists David Julius and Ardem Patapoutian won the 2021 Nobel Prize for Medicine on Monday for the discovery of receptors in the skin that sense temperature and touch and could pave the way for new pain-killers.

Their work, carried out independently, has helped show how humans convert the physical impact from heat or touch into nerve impulses that allow us to “perceive and adapt to the world around us,” the Nobel Assembly at Sweden’s Karolinska Institute said.

“This knowledge is being used to develop treatments for a wide range of disease conditions, including chronic pain.”

Patapoutian, who was born in 1967 to Armenian parents in Lebanon and moved to Los Angeles in his youth, learnt of the news from his father as he had been out of contact by phone.

“In science many times it is the things we take for granted that are of high interest,” he said of winning the more than century-old prize, which is worth 10 million Swedish crowns ($1.15 million).

He is credited for finding the celular mechanism and the underlying gene that translates a mechanical force on our skin into an electric nerve signal.

“(For) us being in the field of sense, touch and pain, this was the big elephant in room where we knew they existed, we knew they did something very different,” he said.

Patapoutian is a professor at Scripps Research, La Jolla, California, having previously done research at the University of California, San Francisco, and California Institute of Technology, Pasadena.

New York-born Julius, 65, is a Professor at University of California, San Francisco (UCFS), after earlier work at Columbia University, in New York.

His findings were inspired by his fascination for how natural products can be used to probe biological function and he used capsaicin, the molecule that makes chili peppers spicy by simulating a false sensation of heat, to understand the skin’s sense of temperature.

1/6

Thomas Perlmann, Secretary of the Nobel Assembly and the Nobel Committee, announces the winners of the 2021 Nobel Prize in Physiology or Medicine David Julius and Ardem Patapoutian (seen on the screen) during a press conference at the Karolinska Institute in Stockholm, Sweden October 4, 2021. T TT News Agency/Jessica Gow via REUTERS

Julius hopes his work will help identify new strategies for treating chronic pain syndromes.

“We all know there’s a real lack of drugs and approaches to treat chronic pain,” Julius said in a 2017 video posted on Youtube by UCSF. “I think we need some new insights and new ideas for treating pain, pharmacologically and other ways, and I think our work will contribute to that.”

Jan Adams, chief science officer at German drugmaker Gruenenthal GmbH, which markets pain relief skin patches and creams based on the TRPV1 capsaicin receptor discovered by Julius, said his work had “opened up a whole new field of research for new non-opioid pain therapies”.

SURPRISE AND SHOCK

Both laureates were caught off guard, according to the committee. Professor Thomas Perlmann, Secretary-General for the Nobel Assembly and the Nobel Committee for Physiology or Medicine, described them as “incredibly happy and as far as I could tell very surprised and a little bit shocked.”

The prestigious Nobel prizes, for achievements in science, literature and peace, were created and funded in the will of Swedish dynamite inventor and businessman Alfred Nobel. They have been awarded since 1901, with the economics prize first handed out in 1969.

The Nobel Prize for Physiology or Medicine, shared in equal parts this year by the two laureates, often lives in the shadow of the Nobels for literature and peace, and their sometimes more widely known recipients.

But medicine has been thrust into the spotlight by the COVID-19 pandemic, and some scientists had suggested those who developed coronavirus vaccines could be rewarded this year or in coming years.

The pandemic continues to haunt the Nobel ceremonies, which are usually full of old-world pomp and glamour. The banquet in Stockholm has been postponed for a second successive year amid lingering worries about the virus and international travel. read more

($1 = 8.7272 Swedish crowns)

Ludwig Burger reported from Frankfurt, Additional reporting Terje Solsvik in Oslo and by Niklas Pollard, Johan Ahlander, Simon Johnson, Supantha Mukherjee and Anna Ringstrom in Stockholm, Editing by Timothy Heritage

Artsakh reports 2 daily coronavirus cases

Save

Share

 12:35, 28 September, 2021

STEPANAKERT, SEPTEMBER 28, ARMENPRESS. 2new cases of COVID-19 were confirmed in Artsakh on the past 24 hours, the ministry of healthcare said.

54 COVID-19 tests were conducted on September 27.

At the moment, 26 infected patients receive treatment in hospitals. 4 are in serious condition.

The ministry again urged the citizens to follow all the rules, to get vaccinated to avoid the new outbreaks and overcome the virus.

 

Editing and Translating by Aneta Harutyunyan

PACE sets out steps to address humanitarian consequences of conflict between Armenia and Azerbaijan over Nagorno-Karabakh

Council of Europe
Sept 29 2021
PARLIAMENTARY ASSEMBLY SESSION STRASBOURG 29 SEPTEMBER 2021

Following the recent conflict between Armenia and Azerbaijan / Nagorno-Karabakh conflict, PACE has set out a series of recommendations to both countries to address the humanitarian consequences in the short and long term, and move towards a process of peace and reconciliation.

Approving a resolution and recommendation on the basis of a report by Paul Gavan (Ireland, UEL), who visited both countries, the Assembly said it was “concerned about the many allegations of crimes, war crimes and other wrongful acts,” during the six-week war, listing the most serious. It called on both countries to “fully investigate the allegations and bring to justice anyone, including at command level, found to be responsible” and to co-operate fully with the European Court of Human Rights on the complaints lodged against them. “Unless there is accountability and some form of truth and reconciliation, these allegations will poison relations between the two countries for generations, and the consequences of the conflict will linger,” the parliamentarians pointed out.

While welcoming the recent release by Azerbaijan of 15 Armenians on 12 June 2021 and a further release of 15 persons on 3 July 2021, bringing the total of those repatriated to above 100, the Assembly also called on the Azerbaijani authorities to release all remaining captives and return them to Armenia without further delay.

Turkish press: Turkish, Russian presidents discuss regional issues, bilateral ties: Kremlin

Ali Cura and Dmitri Chirciu   |30.09.2021

MOSCOW

Turkish and Russian presidents discussed bilateral ties and regional issues during their meeting held on Wednesday, the Kremlin spokesman said on Thursday.

The duo discussed developments in Syria’s Idlib, stressed the importance of bilateral agreements between the two countries and reaffirm their commitment to the agreements, Dmitry Peskov told reporters.

The leaders also exchanged views on developments in Afghanistan, Libya and Nagorno-Karabakh, Peskov said, adding the Russian side said that parties should seek negotiated solutions on the delimitation of borders and the development of transport infrastructure in Nagorno-Karabakh.

Relations between the former Soviet republics of Azerbaijan and Armenia have been tense since 1991, when the Armenian military occupied Nagorno-Karabakh, also known as Upper Karabakh, a territory internationally recognized as part of Azerbaijan, and seven adjacent regions.

New clashes erupted last September and ended on Nov. 10 with a Russian-brokered cease-fire.

During the 44-day conflict, Azerbaijan liberated several cities and nearly 300 settlements and villages from Armenia’s nearly three-decade occupation.

Peskov said that Putin and Erdogan also talked about natural gas and its supply.

“Putin greatly appreciated the timely and effective decisions of the Turkish administration regarding the TurkStream project. Decisions were made quickly, everything was implemented on time, very quickly,” he said.

Peskov said that at a time when the prices of the natural gas and energy market in Europe increased, Turkey felt safe against such sudden changes with all its existing infrastructure.

The Kremlin spokesman said that the two leaders also discussed the continuation of military technical cooperation and the expansion of contacts regarding the S-400 air defense missile systems.

“The possibility of producing some parts of the S-400 in Turkey was also discussed,” said Peskov.

Recalling that the US removed Turkey from the F-35 fighter jet program, Peskov said that cooperation in the field of aviation between Turkey and Russia was on the agenda.

“Putin and Erdogan also discussed major projects on the joint agenda. First, the schedules for continuing construction and completing the first power unit of Akkuyu Nuclear Power Plant. They talked about the possible construction of new units and what needs to be done in general in terms of our cooperation for the emerging sector of the peaceful atom, nuclear energy in Turkey,” Peskov said.

Peskov said that Putin brought up the issue of the cooperation in the field of space and the two leaders touched upon the “Turkish cosmonaut preparations.”

Putin and Erdogan discussed the COVID-19 pandemic and vaccination, the two leaders stressed the importance of vaccination in fight against the pandemic.

*Writing By Busra Nur Cakmak in Ankara

Miss Universe Armenia 2021 results: Monika Grigoryan crowns Nane Avetisyan in Yerevan

Conan Daily
Sept 23 2021



beauty pageantMiss Universe Armenia
  • edition: 3rd
  • date: September 21, 2021
  • venue: Jivan Restaurants, Yerevan, Armenia
  • number of candidates: 15

.

  1. Manan Hunanyan (Yerevan)
  2. Mane Baghirian (Vanadzor)
  3. Marina Karapetyan (Yerevan)
  4. Lia Sargsyan (Vanadzor)
  5. Diana Lepejyan (Yerevan)
  6. Vivana Assatouri (Yerevan)
  7. Liana Yeghiazaryan (Yerevan)
  8. Alla Karapetyan (Martuni)
  9. Annia Andriasian (Yerevan)
  10. Nane Avetisyan (Yerevan)
  11. Adriana Galstyan (Hrazdan)
  12. Amest Arutyunyan (Sisian)
  13. Natali Arutyunyan (Yerevan)
  14. Karolina Gevorgyan (Yerevan)
  15. Sona Hoveyan (Yerevan)

.

  1. Vika Martirosyan (Yerevan)
  2. Arthur Vardapetyan (Yerevan)
  3. Ruzanna Tarannik (Florida, United States)
  4. Aga Kankayan (Yerevan)
  5. Tigran Arakelian (France)
  6. Talia Aibedullina (Russia)
  7. Kamo Mirzoyan (Russia)
  8. Jama Asangulova (Kyrgyzstan)
  9. Edgar Saakyan (Russia)

A new February Uprising in Armenia?

Sept 18 2021
by GUEST CONTRIBUTOR



The events held in Armenia after the early elections of the National Assembly on June 20 2021, are more and more reminiscent of the situation in Armenia before the February revolt of 1921, a burst of despair that had catastrophic historical and political consequences for Armenia.

The political persecution of opposition figures, especially the decapitation of the Syunik region, the unreasonable removal of the respected officers from the army, primitive quarrels in the National Assembly in the face of growing security crisis, consistent tensions of the whole situation intended to create an atmosphere of deep despair, as it was in February 1921. 

Thus, after establishing the Soviet regime in Armenia on December 2, 1920, Russian-Turkish negotiations determined the new Russian-Turkish borders.

However, the presence of the Armenian side in those negotiations could have caused unnecessary problems on the border issues.

Therefore, it was necessary to create a situation that would make the participation of the Armenian SSR impossible and enable the Bolsheviks to draw the borders of Armenia at their own discretion. 

The Revolutionary Committee of Armenia, violating the Armenian-Russian agreement (commonly known as the Dro-Legran Agreement) in December 1920 – February 1921 created an unbearable atmosphere of repressions and persecution.

The arrests and massacres of more than two hundred Armenian officers, politicians and intellectuals on the night of 10 February 1921 was the last drop that overfilled the cup of patience and forced people to raise a rebellion led by the Armenian Revolutionary Federation, suspending the power of the Revolutionary Committee at least in the Ararat Valley. 

When analyzing the course and chronology of the February uprising, one can mention that the Revolutionary Committee handed over Yerevan almost without resistance and pulled back its armed forces to Akhta (currently Hrazdan) and Khamarlu (currently Artashat), in the north to Aparan; and in the West were Turkish troops.

The situation was completely advantageous for the Bolsheviks, since Alexander Bekzadyan, the People’s Commissar of Foreign Affairs of Soviet Armenia had no grounds to participate in the Russian-Turkish negotiations in Moscow, and the “Salvation Committee of the Fatherland” blocked in Yerevan was isolated from the external world with having no chance of survival.

The plan worked.

Alexander Bekzadyan did not take part in the Russian-Turkish conference in Moscow due to the fact that the government he represented did not exist anymore, and the Salvation Committee of the Fatherland was eliminated within two weeks after signing the Moscow Treaty. 

Today through consistent processes despair and deadlock is becoming embedded within the patriotic and honest layers of the Armenian society, thus creating fertile ground for the uprising and rebellions (especially organized by Russia-Turkey-Azerbaijan – the black triangle special forces to proceed with predetermined scenario). 

This will give the Kremlin a so-called legal basis to implement actions envisaged within the framework of the CSTO or the Armenian-Russian interstate agreements and ultimately diminish the Armenian statehood.

This will lead to chaos in Armenia driven by foreign forces, and once again the issues with Armenian borders will be resolved without Armenia’s participation, and the local agents of the black triangle will get a “chance” to blame each other further. 

Post Scriptum: Not to give the reader the impression that we argue the Right of Rebellion, let us also remind you that in 1920-21 Garegin Nzhdeh disobeyed the order from Yerevan to leave Syunik since he knew the significance of Syunik for Armenia’s survival.

Unlike the Yerevan leaders, Nzhdeh also had a strategic understanding of geopolitical processes, will and knowledge to keep Syunik until the Russian-Turkish trade was over.

Moreover, the rebellious Syunik became the lifeline for the rescued Armenian intelligence, later playing a key role in Armenian communities. 

Today Syunik is beheaded. The logic of the ongoing processes suggests that we are witnessing the penultimate round of the Lenin-Kemal-2 operation: to initiate an imitation of a real rebellion by Black triangle’s local agents and puppets, which will ultimately push out Armenia even from the minimal participation in political processes, as well as discredit the idea of a real resistance. 

If the heirs of the two-year-old First Republic, after a thousand years of stateless existence, may have had excuses about not understanding the fundamental driving forces and goals of historical political processes, we need to understand the lessons of 1920-21 a hundred years later, since the price of these events was irreparable. 

Therefore, systematic actions based on the fundamental understanding of geopolitical and historical processes is the only way to stop this destructive wheel. 

By the Armenian Network State Foreign Affairs Think Tank special for Greek City Times 


Central Bank of Armenia: exchange rates and prices of precious metals – 16-09-21

Save

Share

 17:43,

YEREVAN, 16 SEPTEMBER, ARMENPRESS. The Central Bank of Armenia informs “Armenpress” that today, 16 September, USD exchange rate down by 0.63 drams to 486.37 drams. EUR exchange rate down by 3.32 drams to 572.46 drams. Russian Ruble exchange rate up by 0.01 drams to 6.72 drams. GBP exchange rate down by 1.26 drams to 672.07 drams.

The Central Bank has set the following prices for precious metals.

Gold price up by 29.36 drams to 28099.19 drams. Silver price up by 3.20 drams to 372.71 drams. Platinum price down by 175.64 drams to 14714.56 drams.

Two new stamps depict Ghazanchetsots Cathedral of Shushi

Public Radio of Armenia
Sept 14 2021


A souvenir sheet with two postage stamps under the theme “Bombing of Ghazanchetsots Holy Savior Cathedral of Shushi” has been put into circulation, HayPost informs.

The postage stamp of the souvenir sheet with the nominal value of 940 AMD depicts Ghazanchetsots Holy Savior Cathedral of Shushi (XIX c.) and the postage stamp of the souvenir sheet with the nominal value of 950 AMD depicts Ghazanchetsots Holy Savior Cathedral damaged by the strikes of Azerbaijani unmanned aerial vehicles.

The left part of the souvenir sheet depicts Ghazanchetsots Holy Savior Cathedral of Shushi before the bombing as well as one of the angel sculptures of the church. The right part of the souvenir sheet depicts Ghazanchetsots Holy Savior Cathedral, being bombed as a result of the Azerbaijani aggression, as well as the unmanned aerial vehicle.

Date of issue: 
Designer: David Dovlatyan
Stamp size: 40,0 x 30,0 mm
S/sheet size: 105,0 x 70,0 mm
Print run: 25 000 pcs

Kooyrigs Supports Armenia Post-War

Sept 11 2021

PASADENA, California — On November 10, 2020, Armenia and Azerbaijan agreed to a ceasefire in a 44-day war incited by a territory dispute in Nagorny Karabakh. The history of the dispute goes back decades. Nagorny Karabakh was initially Azerbaijan’s territory in the Soviet Era until the majority-Armenian population attempted to separate from Azerbaijan in an attempt for independence. This resulted in a war from 1991-1994.

After extensive fighting and death, Russia brokered a cease-fire agreement. Turkey provided Azerbaijan direct assistance through “military trainers, drones and equipment.” While international support could be largely vacant, a U.S.-based NGO named Kooyrigs was able to step up during these times. It provided support for Armenian soldiers, civilians and mothers suffering from desolation before and after the war.

Executive Director Karine Eurdekian founded Kooyrigs, a project that stemmed from Eurdekian’s time as an ESL teacher for an Armenian Women’s Research Center. Kooyrigs formed as a safe space on Instagram for anonymous conversations between Armenian women in various regions in the diaspora. This enabled Eurdekian to develop a supportive network before the 2020 Armenian-Azerbaijan conflict.

After receiving more than $150,000 in individual donations and a $25,000 grant from Family Foundation, Kooyrigs was ready to offer immediate support through grassroots action. Maro Matosian, the founder of the Women’s Support Centre in Yerevan, spoke in an Insider interview: “[Kooyrigs] also provided us almost with $14,000 of medical supplies and crutches that we sent according to the request of Stepanakert Hospital and Goris Hospital.”

Armenian troops suffered under Azerbaijani artillery, and frontline soldiers were in need of immediate support. Kooyrigs initiated the Looys campaign, a program where team members deliver “food, water, medication, clothing, diapers, formula, sanitary products and household essentials” to some of those most affected by the war.

In an interview with The Borgen Project, Eurdekian said that Kooyrigs was the most immediate source of distribution during the conflict, with team members being the first response to distribute medicines to hospitals. She stated that they risk their lives by transporting supplies to warzones surrounded by Azerbaijanian military drones.

Eurdekian explained how the Kooyrigs Armenia team quickly recognized that “[w]hile the government was providing food for the soldiers that were registered in the system, they didn’t [missing verb] a lot of the time provide food for the volunteer soldiers.” Armenians connected through the Kooyrigs forum revealed that their volunteering relatives hadn’t eaten in weeks. The team members responded by delivering food from rural Armenian farmers in every municipality. Soldiers received familiar, regional food grown in local farms, delivered regularly and transported in trucks with temperature-controlled storage units.

The destruction of homes, cities and families has left Armenia in a societal depression. Children were among those who suffered the most. Separated from their homes and thrust into fractured environments, Armenian children and families experience notable mental challenges. Armenian therapists cite young experiences with war bombings and displacement from homes to local hotels as triggers for anxiety and more. Indeed, the Society for Orphaned Armenian Relief reports that “[w]hile the loss of our fallen Armenian soldiers is itself a tragedy, the war has had the secondary effect of leaving children fatherless and mothers and families without their primary breadwinner.”

Eurdekian currently runs project Mayreeg as well, which is set to provide care packages for pregnant mothers in Armenia. The packages contain a month’s worth of baby products as well as connections to classes meant to help mothers find community. Furthermore, Kooryigs will find doctors, help coordinate birth plans and help pregnant mothers through the birthing process step by step. Eurdekian and her team have seen how stress and trauma have caused a boom in miscarriages in Armenia.

The team uses resources from Yerevan to supply rural areas and spotlights mothers and their children to motivate further donations. The Kooryigs Instagram recently highlighted Tamara, a mother of two who was displaced from Stepenarket and unable to afford education for her oldest child. Tamara suffered through a stress-induced, premature birth. Kooyrigs raised $4,000 the day after posting her profile, which provides her son with a kindergarten education and has helped relocate the family to Yerevan, dramatically changing Tamara’s life.

The war effort enlisted many DJs and artists who had been spreading music throughout the streets of Yerevan. This stunted the spread of music even more so after the COVID restrictions prevented clubs and venues from opening. Kooyrigs collaborated with Zach Asdourian, the Chief A&R of the creative label “Critique,” on an album called YERAZ [Past, Present and Future Armenian Sounds From Los Angeles to Yerevan]. All of the “net profits” from the YERAZ (meaning Dream) album will go toward Kooyrigs’ educational projects. Currently, the album contains “electronic beats with neo-soul tunes, instrumental sounds and folk melodies.” Additionally, it added to the large electronic scene within Armenia.

Eurdekian describes the electronic scene coming together during the war and reinforces how underground clubs in Yerevan became a safe space for young Armenians. One of Yerevan’s popular underground clubs “Poligraf,” where young Armenians enjoyed themselves despite the external situation, hosted the album’s release. It also supported the Kooyrigs cause by buying merchandise or prints. Eurdekian says that the YERAZ album is a “pocket of joy” for people getting through the war. She told The Borgen Project that the album “is just one of those things that we can invest in that is for the culture, for preservation and is proactive as opposed to what’s reactive in the war immediately.”

Kooyrigs serves as a symbol of homecoming for young Armenians in diasporas who are negatively impacted by the older generation’s view of war, tragedy and genocide within their country. These old tragedies repeat in different ways. However, people like Eurdedian have taken the opportunity to focus on an approach that centers a focus on care, direct aid and those in need. Historical moments like the Armenia-Azerbaijan war create new generations of leaders who pick up lessons from elders to pave the way into a brighter future.

– Matthew Martinez


Newspaper: Commander of Russia peacekeepers in Artsakh instructs to destroy Azerbaijan equipment

News.am, Armenia
Sept 9 2021

YEREVAN. – Hraparak daily of the Republic of Armenia (RA) writes: Relations between the Russian peacekeepers stationed in Artsakh [(Nagorno-Karabakh)] and the Azerbaijanis are becoming increasingly tense. In recent times, the Azerbaijanis have been provoking on a daily basis—they block the road in the Shushi [city] section, violate the ceasefire regime by opening random fire, sometimes in the direction of [the Artsakh capital] Stepanakert, too.

According to Artsakh sources, the Azerbaijani side is provoking in a planned way, trying to show that they are in charge of the situation, the peacekeepers are temporary and do not establish peace [in the region]. According to our source, the Artsakh and RA authorities—which do not respond to these provocations, do not issue messages about [the Azerbaijanis] violating the ceasefire, do not send notes [of protest], do not draw the attention of the international community to the incidents—give them [i.e., the Azerbaijanis] a green light.

Recently, the Azerbaijanis have concentrated equipment at the beginning of the road to Shushi, as if they are building the road. The road leading to Stepanakert was closed for several hours, the news reached the [Russian] peacekeepers. Rustam Muradov [i.e., the commander of these peacekeepers] contacted the Azerbaijani patrol, who replied that, “So we are doing. Isn’t it our road? We will do whatever we want.” Muradov sent 2 BTRs [i.e., armored personnel carriers] to the “scene of the incident,” and instructed to destroy the Azerbaijani equipment. They did so; they pushed, threw the tractor that blocked the road into the gorge.

Let us remind that Muradov’s period of service [in the aforesaid capacity] has ended, according to our information, he will be replaced by Major General Mikhail Kosobokov.